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KMID : 0624620230560070410
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BMB Reports
2023 Volume.56 No. 7 p.410 ~ p.415
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Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1
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Park Ji-Young
Lee Se-Woong
Yoon Hae-Lim
Kang Eun-Jeong
Cho Sa-Yeon
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Abstract
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Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast cancer cells into metastatic sites. Therefore, targeting Twist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. LY-290181 inhibited extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling pathways. Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers.
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KEYWORD
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Breast cancer, EMT, LY-290181, TNBC, Twist1
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